Acarbose (ITP-validated geroprotector)

nutrient sensingmetabolic glycemic

Approved medicine for another condition in 6 of 9 markets tracked; in clinical trials in 1.

1 randomized trial (43 people, 13 weeks). Of its 3 main endpoints, 1 improved, 1 worsened, 1 showed no effect.

Doses studied: 50 mg single dose.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (7)

T7 Madden 2025 The Effects of Acarbose on the Postprandial Hypotensive Response in Older Adults doi:10.1017/S0714980825100056
T5 Tseng 2020 Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone doi:10.14336/ad.2019.0621
T3 Moore 2026 Acarbose improves cognitive function in a mouse model of normal aging but not Alzheimer’s disease doi:10.64898/2026.04.28.721469
T3 Jiang 2022 A cocktail of rapamycin, acarbose and phenylbutyrate prevents age-related cognitive decline in mice by altering aging pathways doi:10.1101/2022.09.07.506968
T3 Harrison 2013 Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males doi:10.1111/acel.12170
T3 Harrison 2019 Acarbose improves health and lifespan in aging HET3 mice doi:10.1111/acel.12898
T3 Shen 2021 Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol doi:10.1111/acel.13345