Where healthspan treatments stand, market by market.
How far each development has come with regulators and in use, across 9 markets, and what it was actually approved for. Every stage links to its source, and the gaps between markets are computed, not estimated.
40 developments in 16 mechanism classes, tracked across 9 markets (CH·CN·IL·IN·JP·KR·SG·UK·US) from 424 sourced observations. 4 show one market clearly ahead of the others.
Where one market is furthest ahead
Acarbose (ITP-validated geroprotector)
repurposed · alpha-glucosidase-inhibition, postprandial-glucose
United Kingdom leads by 4 stages. Singapore reached it about 30 years before Israel.
INJP6 marketsTaurine (amino acid, aging research)
traditional-to-validated · amino-acid, mitochondrial-support
Japan leads by 4 stages.
KRCNJPUSN-acetylcysteine (glutathione precursor)
repurposed · glutathione-synthesis, antioxidant
Switzerland leads by 2 stages and reached it about 57 years before Japan.
UK7 markets17α-Estradiol (17α-E2), longevity use
repurposed · estrogen-receptor-independent, metabolic-aging
South Korea leads by 3 stages.
USKR
Every development, by class
Stage in each market for all 40 developments. The shade deepens from early signal to consumer sale; the Gap column shows how many stages the furthest-ahead market leads by. Open a name for its sources.
| Development | US | UK | CN | IN | JP | CH | SG | IL | KR | Gap |
|---|---|---|---|---|---|---|---|---|---|---|
| mTOR inhibitors · 3 | ||||||||||
| Everolimus (RAD001), immune-aging | approved | approved | approved | · | approved | approved | approved | approved | approved | · |
| Rapamycin (sirolimus), longevity use | approved | approved | approved | real-world | approved | approved | approved | approved | approved | +1 |
| Temsirolimus (mTOR inhibitor) | approved | approved | · | · | approved | RCT | RCT | · | approved | +1 |
| Senolytics · 4 | ||||||||||
| Dasatinib (senolytic use) | approved | approved | approved | RCT | approved | approved | approved | approved | approved | +1 |
| Fisetin (senolytic flavonoid) | consumer | · | signal | · | · | · | · | · | · | · |
| Navitoclax (senolytic, ABT-263) | RCT | RCT | · | · | RCT | RCT | · | RCT | RCT | · |
| Quercetin (senolytic flavonoid) | consumer | · | RCT | · | · | · | · | · | · | · |
| Incretins · 4 | ||||||||||
| Dulaglutide (GLP-1 agonist) | approved | approved | approved | RCT | approved | approved | approved | approved | approved | +1 |
| Liraglutide (GLP-1 agonist) | approved | approved | approved | RCT | approved | approved | approved | approved | approved | +1 |
| Semaglutide (GLP-1, healthspan) | approved | approved | approved | RCT | approved | approved | approved | approved | approved | +1 |
| Tirzepatide (GIP / GLP-1 dual agonist) | approved | approved | approved | RCT | approved | approved | approved | approved | approved | +1 |
| SGLT2 inhibitors · 3 | ||||||||||
| Canagliflozin (SGLT2 inhibitor) | approved | approved | approved | RCT | approved | approved | approved | RCT | RCT | +1 |
| Dapagliflozin (SGLT2 inhibitor) | approved | approved | approved | RCT | approved | approved | approved | approved | approved | +1 |
| Empagliflozin (SGLT2 inhibitor) | approved | approved | approved | RCT | approved | approved | approved | approved | approved | +1 |
| Alpha-glucosidase · 1 | ||||||||||
| Acarbose (ITP-validated geroprotector) | approved | approved | approved | signal | RCT | · | approved | approved | approved | +4 UK |
| AMPK / biguanide · 2 | ||||||||||
| Berberine (AMPK activator) | consumer | · | approved | · | · | · | · | RCT | · | +1 |
| Metformin, longevity use | approved | approved | approved | RCT | approved | approved | approved | approved | approved | +1 |
| NAD+ precursors · 3 | ||||||||||
| NMN (NAD+ precursor) | consumer | · | RCT | · | · | · | signal | · | · | +3 |
| Niacin (vitamin B3, NAD+ precursor) | consumer | · | · | · | · | signal | · | RCT | · | +3 |
| Nicotinamide riboside (NAD+ precursor) | consumer | RCT | · | · | · | signal | · | · | · | +3 |
| Sirtuin activators (STAC) · 2 | ||||||||||
| Pterostilbene (sirtuin activator, STAC) | consumer | · | · | · | · | · | · | · | · | · |
| Resveratrol (sirtuin activator, STAC) | consumer | first-in-human | RCT | · | · | · | RCT | signal | · | +3 |
| Mitophagy · 1 | ||||||||||
| Urolithin A (mitophagy inducer) | consumer | · | · | · | · | · | signal | · | · | · |
| Autophagy · 2 | ||||||||||
| Spermidine (autophagy inducer) | consumer | · | RCT | · | · | · | · | · | · | · |
| Trehalose (autophagy inducer) | consumer | · | · | · | · | · | · | · | · | · |
| Amino-acid / glutathione · 3 | ||||||||||
| Glycine (amino acid, GlyNAC) | consumer | · | · | · | · | · | signal | RCT | · | +3 |
| N-acetylcysteine (glutathione precursor) | approved | first-in-human | approved | · | approved | approved | approved | approved | approved | +2 CH |
| Taurine (amino acid, aging research) | consumer | · | RCT | · | approved | · | · | · | signal | +4 JP |
| Mitochondrial · 4 | ||||||||||
| Alpha-lipoic acid (mitochondrial antioxidant) | consumer | RCT | signal | · | · | · | · | · | RCT | +3 |
| Coenzyme Q10 (mitochondrial cofactor) | consumer | · | RCT | · | RCT | · | RCT | RCT | · | · |
| Creatine (muscle energy buffer) | consumer | · | signal | · | · | · | · | · | · | · |
| MitoQ (mitochondria-targeted antioxidant) | RCT | RCT | · | · | · | RCT | · | · | · | · |
| Antioxidant / Nrf2 · 1 | ||||||||||
| Nordihydroguaiaretic acid (NDGA) | preclin | · | · | · | · | · | · | · | · | · |
| Inflammaging · 2 | ||||||||||
| Colchicine (anti-inflammatory) | approved | approved | approved | · | approved | approved | approved | approved | approved | · |
| Omega-3 fatty acids (fish oil) | consumer | · | signal | · | · | · | signal | · | signal | · |
| Sex-hormone geroprotectors · 1 | ||||||||||
| 17α-Estradiol (17α-E2), longevity use | preclin | · | · | · | · | · | · | · | approved | +3 KR |
| Other · 4 | ||||||||||
| Collagen peptides | consumer | · | · | · | · | · | · | · | · | · |
| Magnesium (mineral cofactor) | consumer | signal | · | · | · | · | · | · | · | · |
| Probiotics (gut microbiome) | consumer | signal | RCT | · | · | · | · | · | RCT | +3 |
| Vitamin D (D3, cholecalciferol) | consumer | signal | signal | · | signal | · | RCT | signal | · | +3 |
No development matches that name.