Market atlas / Autophagy / Trehalose

Trehalose (autophagy inducer)

traditional-to-validatedsmall-moleculeautophagy-inductiondisaccharide● autophagy

Stage by geography

signalpreclinfirst-in-humanRCTapprovedreal-worldconsumerUS

MarketsUS United States FDAUK United Kingdom MHRA / NICECN China NMPAIN India CDSCOJP Japan PMDACH Switzerland SwissmedicSG Singapore HSAIL Israel Ministry of HealthKR South Korea MFDS

What each market approved it for

Market	Stage	Since	Indication / class / form
US	consumer	not dated	not published

Legal status by market

Market	Legal class	Effective	Status & source
US	Dietary supplement	not dated	Sold as a US dietary supplement and GRAS food ingredient; no FDA drug approval. DSLD:330895

Biomarker trends

no biomarker readings yet

Studies

The studies on Trehalose, what they found, in whom and how strongly, are on its evidence page, each linked to its source.

What the trials measure

Registered primary outcomes this development's trials are powered on, commonest first (ClinicalTrials.gov). What is measured, across markets.

Registered primary endpoint	Markets measuring it
Safety and tolerability of escalating doses of intravenously administered trehalose (incidence of adverse events and serious…	US
Disease Progression	US
Corneal epithelial permeability	US
Nitric Oxide Mediated Endothelium-Dependent Vasodilation via Laser Doppler Flowmetry Coupled with Intradermal Microdialysis	US
Autophagic Flux Protein Expression	US
Arterial Stiffness	US
Nitric-oxide mediated endothelium-dependent dilation	US

Connections

Trajectory

2020

Relatedshares a mechanism with Spermidine

NCT04297683 · machine-extracted

2020

ProfileTrehalose (autophagy inducer)

NCT04297683 · machine-extracted

2020

MarketUS: rct (clinical trials (highest phase 3))

NCT04297683 · machine-extracted

2026

MarketUS: consumer (US dietary supplement / food ingredient (GRAS))

DSLD:330895 · machine-extracted

2026

Legal statusUS: dietary supplement. Sold as a US dietary supplement and GRAS food ingredient; no FDA drug approval.

DSLD:330895 · machine-extracted

Get into the weeds: raw observations + provenance

tre_edge_sperm  2026-06-29  kind=edge  verify=M
   both autophagy inducers
   source NCT04297683  https://clinicaltrials.gov/study/NCT04297683

tre_facets  2026-06-29  kind=facets  verify=M
   Trehalose facets
   source NCT04297683  https://clinicaltrials.gov/study/NCT04297683

tre_us_trial  2026-06-29  kind=geography_stage  verify=M
   Trehalose: US phase 3 trials [NCT04297683]
   source NCT04297683  https://clinicaltrials.gov/study/NCT04297683

tre_us_consumer  2026-06-29  kind=geography_stage  verify=M
   Trehalose sold as a US dietary supplement and food ingredient
   source DSLD:330895  https://dsld.od.nih.gov/label/330895

legal__US__dev_trehalose  2026-07-21  kind=legal_status  verify=M
   dev_trehalose in US: dietary-supplement (Sold as a US dietary supplement and GRAS food ingredient; no FDA drug approval.)
   source DSLD:330895  https://dsld.od.nih.gov/label/330895