Market atlas / Autophagy / Spermidine
Spermidine (autophagy inducer)
traditional-to-validatedsmall-moleculeautophagy-inductionpolyamine● autophagy
Stage by geography
signalpreclinfirst-in-humanRCTapprovedreal-worldconsumerUSCN
MarketsUS United States FDAUK United Kingdom MHRA / NICECN China NMPAIN India CDSCOJP Japan PMDACH Switzerland SwissmedicSG Singapore HSAIL Israel Ministry of HealthKR South Korea MFDS
What each market approved it for
| Market | Stage | Since | Indication / class / form |
|---|---|---|---|
| US | consumer | not dated | not published |
| CN | RCT | 2025-06-25 | not published |
Biomarker trends
no biomarker readings yet
Studies
The studies on Spermidine, what they found, in whom and how strongly, are on its evidence page, each linked to its source.
What the trials measure
Registered primary outcomes this development's trials are powered on, commonest first (ClinicalTrials.gov). What is measured, across markets.
| Registered primary endpoint | Markets measuring it |
|---|---|
| Radiation-induced xerostomia | CN |
| Triglycerides (TG) | CN |
Connections
Trajectory
2026
MarketUS: consumer (US dietary supplement (DSHEA), not FDA-approved as a drug)
DSLD:332497 · machine-extracted
Get into the weeds: raw observations + provenance
sperm_cn 2026-06-29 kind=geography_stage verify=M Spermidine: registered phase 2 trials in China [NCT07035626] source NCT07035626 https://clinicaltrials.gov/study/NCT07035626 sperm_edge_rapa 2026-06-29 kind=edge verify=M both induce autophagy (spermidine directly, rapamycin via mTOR inhibition) source NCT07058974 https://clinicaltrials.gov/study/NCT07058974 sperm_facets 2026-06-29 kind=facets verify=M Spermidine facets source NCT07058974 https://clinicaltrials.gov/study/NCT07058974 sperm_us 2026-06-29 kind=geography_stage verify=M Spermidine sold as a US dietary supplement (often as wheat-germ extract) source DSLD:332497 https://dsld.od.nih.gov/label/332497