Overview / Research screener / Spermidine
OTC Nutraceuticals
Spermidine (autophagy inducer)
autophagy mitophagy
Sold as a consumer product in 1 of 9 markets tracked; in clinical trials in 1.
Evidence so far is from observational studies in people and animal studies.
Evidence map
main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported
Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.
What each study measured
Harms reported
Where it is available
If you are tracking this yourself
Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.
What would change this picture
Trials under way
Every study (9)
- T5 Wang 2026 Association between dietary spermidine intake and prostate cancer incidence, stage, and mortality in the PLCO Cancer Screening Trial doi:10.3389/fnut.2026.1775582
- T5 López-González 2025 Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome doi:10.1007/s00394-026-03981-1
- T3 Eisenberg 2016 Cardioprotection and lifespan extension by the natural polyamine spermidine doi:10.1038/nm.4222
- TX Kriebs 2024 Spermidine controls autophagy during fasting doi:10.1038/s43587-024-00710-3
- TX Madeo 2018a Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? doi:10.1080/15548627.2018.1530929
- TX Madeo 2018b Spermidine delays aging in humans doi:10.18632/aging.101517
- TX Jiang 2026 Geroprotective insights into the natural metabolite spermidine in aging and age-related diseases doi:10.1038/s41514-026-00448-9
- TX Rzeski 2026 Natural Bioactive Compounds Targeting Key Hallmarks of Aging: Functional Food Potential of Spermidine, Fisetin, Berberine, and Urolithin A doi:10.3390/nu18152511
- TX Pietrocola 2019 Spermidine reduces cancer-related mortality in humans doi:10.1080/15548627.2018.1539592