Market atlas / Mitophagy / Urolithin A
Urolithin A (mitophagy inducer)
traditional-to-validatedsmall-moleculemitophagy-induction● mitochondrial-function
Stage by geography
signalpreclinfirst-in-humanRCTapprovedreal-worldconsumerUSSG
MarketsUS United States FDAUK United Kingdom MHRA / NICECN China NMPAIN India CDSCOJP Japan PMDACH Switzerland SwissmedicSG Singapore HSAIL Israel Ministry of HealthKR South Korea MFDS
What each market approved it for
| Market | Stage | Since | Indication / class / form |
|---|---|---|---|
| US | consumer | not dated | not published |
| SG | signal | not dated | not published |
Biomarker trends
no biomarker readings yet
Studies
The studies on Urolithin A, what they found, in whom and how strongly, are on its evidence page, each linked to its source.
What the trials measure
Registered primary outcomes this development's trials are powered on, commonest first (ClinicalTrials.gov). What is measured, across markets.
| Registered primary endpoint | Markets measuring it |
|---|---|
| Change in 6 minute walking distance (6MWD) at the end of study intervention compared to baseline | US |
| Percent change from baseline in ATP max (maximal ATP synthesis rate) in hand skeletal muscle (via Magnetic Resonance Spectroscopy) | US |
| Change in arterial function and local stiffness | US |
| Absolute change from T0 to T+24 hours in the Urolithin A (UA) group as compared to Pomegranate Juice (PJ) group in UA-… | US |
| Failure/rejection rate (% of the samples) collected at home by participants. | US |
| To determine if urolithin A supplementation will influence insulin secretion in response to oral glucose at 4 and 8 weeks after… | US |
| Percent positive change in 8-OHdG | US |
| Change from baseline in cardiorespiratory fitness (VO₂peak) | SG |
| Change from baseline in muscle strength (one-repetition maximum (1RM)) | SG |
| Change from baseline in muscle mass (Ultrasound imaging) | SG |
Connections
Trajectory
2026
MarketUS: consumer (US dietary supplement (DSHEA), not FDA-approved as a drug)
DSLD:333435 · machine-extracted
Get into the weeds: raw observations + provenance
ua_edge_sperm 2026-06-29 kind=edge verify=M both promote autophagic/mitophagic clearance source NCT06022822 https://clinicaltrials.gov/study/NCT06022822 ua_facets 2026-06-29 kind=facets verify=M Urolithin A facets source NCT06022822 https://clinicaltrials.gov/study/NCT06022822 ua_us_trial 2026-06-29 kind=geography_stage verify=M Urolithin A: US phase 2 trials [NCT06022822] source NCT06022822 https://clinicaltrials.gov/study/NCT06022822 ua_us_consumer 2026-06-29 kind=geography_stage verify=M Urolithin A (e.g. Mitopure) sold as a US dietary supplement source DSLD:333435 https://dsld.od.nih.gov/label/333435 ctsearch__SG__dev_urolithin_a 2026-07-10 kind=geography_stage verify=M urolithin A: 1 registered trial(s) in SG, highest phase ? [NCT07451496] source NCT07451496 https://clinicaltrials.gov/study/NCT07451496