Urolithin A (mitophagy inducer)

autophagy mitophagynad mitochondrial

Sold as a consumer product in 1 of 9 markets tracked.

3 randomized trials (214 people, 4-17 weeks). 1 improved its main endpoint, a blood or epigenetic marker; 2 found no effect.

Doses studied: 1000 mg/day.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (11)

T7 Singh 2022 Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults doi:10.1016/j.xcrm.2022.100633
T7 Liu 2022 Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults doi:10.1001/jamanetworkopen.2021.44279
T6 Singh 2018 Translating Urolithin A Benefits on Muscle Mitochondria to Humans doi:10.1093/geroni/igy023.351
T5 Tavartkiladze 2026 A Dysbiosis-Urolithin A Depletion-Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States doi:10.3390/ijms27135753
T3 D'Amico 2022 Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis doi:10.1111/acel.13662
T3 Jara 2026 Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment doi:10.1038/s41514-026-00351-3
TX Thakur 2026 Urolithin A: A Novel Postbiotic for inflammation, aging, and cancer: A Journey from Dietary ellagitannins to clinical use doi:10.1007/s11033-026-11950-4
TX Rzeski 2026 Natural Bioactive Compounds Targeting Key Hallmarks of Aging: Functional Food Potential of Spermidine, Fisetin, Berberine, and Urolithin A doi:10.3390/nu18152511
TX Vinciguerra 2022 Urolithin A improves physical performance in middle age doi:10.1038/s43587-022-00239-3
TX Faitg 2023 Mitophagy Activation by Urolithin A to Target Muscle Aging doi:10.1007/s00223-023-01145-5
TX D’Amico 2023 Potential of Urolithin A to improve joint health doi:10.18632/aging.204633