Market atlas / Mitochondrial / Creatine

Creatine (muscle energy buffer)

traditional-to-validatedsupplementphosphocreatine-energy-buffermitochondrial-bioenergetics● muscle-strength● lean-mass

Stage by geography

signalpreclinfirst-in-humanRCTapprovedreal-worldconsumerUSCN

MarketsUS United States FDAUK United Kingdom MHRA / NICECN China NMPAIN India CDSCOJP Japan PMDACH Switzerland SwissmedicSG Singapore HSAIL Israel Ministry of HealthKR South Korea MFDS

What each market approved it for

Market	Stage	Since	Indication / class / form
US	consumer	not dated	not published
CN	signal	not dated	not published

Legal status by market

Market	Legal class	Effective	Status & source
US	Dietary supplement	not dated	Sold as a US dietary supplement; label on file in the NIH Dietary Supplement Label Database (NOW Sports Micronized Creatine Monohydrate). DSLD:245315

Biomarker trends

no biomarker readings yet

Studies

The studies on Creatine, what they found, in whom and how strongly, are on its evidence page, each linked to its source.

What the trials measure

Registered primary outcomes this development's trials are powered on, commonest first (ClinicalTrials.gov). What is measured, across markets.

Registered primary endpoint	Markets measuring it
Serum cardiac troponin I(cTnI)	CN
Change from Baseline in Hamilton Depression Rating Scale	CN
The feasibility of collecting body composition assessments	US
The feasibility of collecting individual physical function assessments	US
Serum Creatinine	US
Urine Creatinine	US

Connections

no connections yet

Trajectory

2026

ProfileCreatine (muscle energy buffer)

NCT06925880 · machine-extracted

2026

MarketUS: consumer (US dietary supplement (DSHEA))

DSLD:245315 · machine-extracted

2026

Legal statusUS: dietary supplement. Sold as a US dietary supplement; label on file in the NIH Dietary Supplement Label Database (NOW Sports Micronized Creatine Monohydrate).

DSLD:245315 · machine-extracted

2026

MarketCN: signal (clinical trials (highest phase ?))

NCT03186053 · machine-extracted

2026

MarketUS: signal (clinical trials (highest phase ?))

NCT05823740 · machine-extracted

Get into the weeds: raw observations + provenance

creatine_facets  2026-09-28  kind=facets  verify=M
   Creatine (muscle energy buffer) facets (mechanism tags pending curator review)
   source NCT06925880  https://clinicaltrials.gov/study/NCT06925880

creatine_us  2026-09-28  kind=geography_stage  verify=M
   Creatine is sold in the US as a dietary supplement (NOW Sports Micronized Creatine Monohydrate)
   source DSLD:245315  https://dsld.od.nih.gov/label/245315

legal__US__otc_creatine  2026-09-28  kind=legal_status  verify=M
   otc_creatine in US: dietary-supplement (Sold as a US dietary supplement; label on file in the NIH Dietary Supplement Label Database (NOW Sports Micronized Creatine Monohydrate).)
   source DSLD:245315  https://dsld.od.nih.gov/label/245315

ctsearch__CN__otc_creatine  2026-09-29  kind=geography_stage  verify=M
   creatine monohydrate: 2 registered trial(s) in CN, highest phase ? [NCT03186053]
   source NCT03186053  https://clinicaltrials.gov/study/NCT03186053

ctsearch__US__otc_creatine  2026-09-29  kind=geography_stage  verify=M
   creatine monohydrate: 2 registered trial(s) in US, highest phase ? [NCT05823740]
   source NCT05823740  https://clinicaltrials.gov/study/NCT05823740