Market atlas / Sex-hormone geroprotectors / 17α-Estradiol
17α-Estradiol (17α-E2), longevity use
repurposedsmall-moleculeestrogen-receptor-independentmetabolic-aginganti-inflammatory● fasting-glucose● il-6
Stage by geography
South Korea leads by 3 stages.
signalpreclinfirst-in-humanRCTapprovedreal-worldconsumerUSKR+3 stages
MarketsUS United States FDAUK United Kingdom MHRA / NICECN China NMPAIN India CDSCOJP Japan PMDACH Switzerland SwissmedicSG Singapore HSAIL Israel Ministry of HealthKR South Korea MFDS
What each market approved it for
| Market | Stage | Since | Indication / class / form |
|---|---|---|---|
| US | preclin | 2016-01-01 | not published |
| KR | approved | 2008-06-16 | class Hair preparations (growth, loss, dyeing, nourishing) [MFDS 02670] |
Biomarker trends
no biomarker readings yet
Studies
The studies on 17α-Estradiol, what they found, in whom and how strongly, are on its evidence page, each linked to its source.
Connections
Trajectory
2008
MarketKR: approved-other (MFDS-approved (South Korea))
MFDS:alfatradiol (2008-06-16) · machine-extracted
Get into the weeds: raw observations + provenance
mfds__dev_17a_estradiol__KR 2026-07-13 kind=geography_stage verify=M MFDS-approved in South Korea: Alfatradiol (ELL-CRANELL ALPHA SOLUTION 0.025%), first approval 2008-06-16. [MFDS drug product-approval list] source MFDS:alfatradiol (2008-06-16) https://nedrug.mfds.go.kr/pbp/CCBGA01 17ae_facets 2026-07-12 kind=facets verify=H 17α-estradiol facets (classification pending curator review) source PMID:27312235 https://doi.org/10.1111/acel.12496 17ae_us 2026-07-12 kind=geography_stage verify=H NIA Interventions Testing Program (US), murine lifespan stage source PMID:27312235 https://doi.org/10.1111/acel.12496 17ae_edge_acar 2026-07-12 kind=edge verify=H co-reported ITP lifespan agent (same program, Strong 2016) source PMID:27312235 https://doi.org/10.1111/acel.12496