Market atlas / Other / Magnesium

Magnesium (mineral cofactor)

traditional-to-validatedsupplementmineral-cofactorglucose-metabolism● serum-magnesium● sleep-quality

Stage by geography

signalpreclinfirst-in-humanRCTapprovedreal-worldconsumerUSUK

MarketsUS United States FDAUK United Kingdom MHRA / NICECN China NMPAIN India CDSCOJP Japan PMDACH Switzerland SwissmedicSG Singapore HSAIL Israel Ministry of HealthKR South Korea MFDS

What each market approved it for

Market	Stage	Since	Indication / class / form
US	consumer	not dated	not published
UK	signal	not dated	not published

Legal status by market

Market	Legal class	Effective	Status & source
US	Dietary supplement	not dated	Sold as a US dietary supplement; label on file in the NIH Dietary Supplement Label Database (Nootropics Depot Magnesium Glycinate). DSLD:232373

Biomarker trends

no biomarker readings yet

Studies

The studies on Magnesium, what they found, in whom and how strongly, are on its evidence page, each linked to its source.

What the trials measure

Registered primary outcomes this development's trials are powered on, commonest first (ClinicalTrials.gov). What is measured, across markets.

Registered primary endpoint	Markets measuring it
Downhill 10 km treadmill time trial performance	UK
24 Hr post exercise maximal force testing of the dominant leg on the isokinetic dynamometer	UK
Ionized magnesium (whole blood)	US
Total magnesium in serum and urine	US
Exploratory / Correlative Outcome Measures	US
Subjective Improvement of Restless Legs Symptoms measured by the International Restless Legs Syndrome Scale (IRLS)	US
Subjective Improvement of Restless Legs Symptoms measured by the Kohnen Kohnen Restless Legs Syndrome Quality of Life Instrument…	US
Objective Improvement of Restless Legs Symptoms: Multiple Suggested Immobilization test (MSI) Score	US
Correlation of magnesium levels with Kohnen Restless Legs Syndrome Quality of Life Instrument (KRLS) and Multiple Suggested…	US
Left ventricular mass (by cardiac MRI)	US

Connections

no connections yet

Trajectory

2026

Legal statusUS: dietary supplement. Sold as a US dietary supplement; label on file in the NIH Dietary Supplement Label Database (Nootropics Depot Magnesium Glycinate).

DSLD:232373 · machine-extracted

2026

ProfileMagnesium (mineral cofactor)

NCT00833092 · machine-extracted

2026

MarketUS: consumer (US dietary supplement (DSHEA))

DSLD:232373 · machine-extracted

2026

MarketUK: signal (clinical trials (highest phase ?))

NCT04216836 · machine-extracted

2026

MarketUS: signal (clinical trials (highest phase ?))

NCT04139928 · machine-extracted

Get into the weeds: raw observations + provenance

legal__US__otc_magnesium  2026-09-28  kind=legal_status  verify=M
   otc_magnesium in US: dietary-supplement (Sold as a US dietary supplement; label on file in the NIH Dietary Supplement Label Database (Nootropics Depot Magnesium Glycinate).)
   source DSLD:232373  https://dsld.od.nih.gov/label/232373

magnesium_facets  2026-09-28  kind=facets  verify=M
   Magnesium (mineral cofactor) facets (mechanism tags pending curator review)
   source NCT00833092  https://clinicaltrials.gov/study/NCT00833092

magnesium_us  2026-09-28  kind=geography_stage  verify=M
   Magnesium is sold in the US as a dietary supplement (Nootropics Depot Magnesium Glycinate)
   source DSLD:232373  https://dsld.od.nih.gov/label/232373

ctsearch__UK__otc_magnesium  2026-09-29  kind=geography_stage  verify=M
   magnesium supplementation: 1 registered trial(s) in UK, highest phase ? [NCT04216836]
   source NCT04216836  https://clinicaltrials.gov/study/NCT04216836

ctsearch__US__otc_magnesium  2026-09-29  kind=geography_stage  verify=M
   magnesium supplementation: 3 registered trial(s) in US, highest phase ? [NCT04139928]
   source NCT04139928  https://clinicaltrials.gov/study/NCT04139928