Magnesium (mineral cofactor)

metabolic glycemicstress neuroendocrine

Sold as a consumer product in 1 of 9 markets tracked.

1 randomized trial (35 people, 12 months). It found no effect on any of its 5 main endpoints.

Doses studied: 200 mg/day.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (8)

T7 Pickering 2026 Quantitative sensory testing of pain in osteoporosis: a pilot randomized clinical trial with magnesium supplementation doi:10.1007/s40520-025-03317-9
T5 Nguyen 2026 Early magnesium administration is associated with lower short-term mortality in sepsis: A propensity score matched cohort study with exploratory stratification by systemic immune-inflammation index doi:10.1097/MD.0000000000049526
T5 Song 2025 Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF doi:10.1038/s41598-025-85931-1
T5 Wang 2023 Magnesium intake and all-cause mortality after stroke: a cohort study doi:10.1186/s12937-023-00886-1
T3 Villa-Bellosta 2020 Magnesium supplementation improves mitochondrial function and extends longevity in a mouse model of Hutchinson-Gilford progeria syndrome doi:10.15252/emmm.202012423
TX Chambers 2025 Magnesium Deficiency Accelerates Aging and Shortens Healthspan doi:10.32388/57LL9Y.2
TX Chambers 2026 The Calcium to Magnesium Ratio: Create a Ratio that Deters Long Covid and Drives Healthy Aging doi:10.32388/U5JTWN.5
TX Barbagallo 2014 Magnesium, Oxidative Stress, and Aging Muscle doi:10.1016/B978-0-12-405933-7.00016-0