Market atlas / Senolytics / Fisetin

Fisetin (senolytic flavonoid)

traditional-to-validatedsmall-moleculesenolytic● senescent-cell-burden

Stage by geography

signalpreclinfirst-in-humanRCTapprovedreal-worldconsumerUSCN

MarketsUS United States FDAUK United Kingdom MHRA / NICECN China NMPAIN India CDSCOJP Japan PMDACH Switzerland SwissmedicSG Singapore HSAIL Israel Ministry of HealthKR South Korea MFDS

What each market approved it for

Market	Stage	Since	Indication / class / form
US	consumer	not dated	not published
CN	signal	2025-09-16	not published

Biomarker trends

no biomarker readings yet

Studies

The studies on Fisetin, what they found, in whom and how strongly, are on its evidence page, each linked to its source.

What the trials measure

Registered primary outcomes this development's trials are powered on, commonest first (ClinicalTrials.gov). What is measured, across markets.

Registered primary endpoint	Markets measuring it
Senescent cell abundance in blood (p16INK4A)	US
Change in Pittsburgh Fatigability Scale (PFS)	US
Change in Walking Speed	US
Incidence of Treatment-Emergent Adverse Events	US
Change in immunophenotyping of peripheral T lymphocytes	US
Change in COVID-19 Severity	US
Change from baseline in endothelial function at 1 month	US
Change in markers of liver toxicity	US
Change in markers of kidney toxicity	US
Change in markers of tumor lysis syndrome	US

Connections

Trajectory

2023

Relatedshares a mechanism with Dasatinib

NCT05482672 · machine-extracted

2023

ProfileFisetin (senolytic flavonoid)

NCT05482672 · machine-extracted

2023

MarketUS: rct (clinical trials (highest phase 3))

NCT05482672 · machine-extracted

2025

MarketCN: signal (early clinical signal (single trial))

NCT06990256 · machine-extracted

2026

MarketUS: consumer (US dietary supplement (DSHEA), not FDA-approved as a drug)

DSLD:332361 · machine-extracted

Get into the weeds: raw observations + provenance

fise_edge_dasa  2026-06-29  kind=edge  verify=M
   both senolytics
   source NCT05482672  https://clinicaltrials.gov/study/NCT05482672

fise_facets  2026-06-29  kind=facets  verify=M
   Fisetin facets
   source NCT05482672  https://clinicaltrials.gov/study/NCT05482672

fise_us_trial  2026-06-29  kind=geography_stage  verify=M
   Fisetin: US senolytic trials (Mayo Clinic and others) in progress [NCT05482672]
   source NCT05482672  https://clinicaltrials.gov/study/NCT05482672

fise_cn  2026-06-29  kind=geography_stage  verify=M
   Fisetin: a single registered trial in China [NCT06990256]
   source NCT06990256  https://clinicaltrials.gov/study/NCT06990256

fise_us_consumer  2026-06-29  kind=geography_stage  verify=M
   Fisetin sold as a US dietary supplement (not FDA-approved as a drug)
   source DSLD:332361  https://dsld.od.nih.gov/label/332361