Fisetin (senolytic flavonoid)

senolytic

Sold as a consumer product in 1 of 9 markets tracked.

Evidence so far is from animal studies.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (6)

T3 Dong 2026 Fisetin Attenuates D-Gal-Induced Ovarian Aging by Modulating Mitophagy via the AMPK/mTOR Pathway doi:10.3390/antiox15050602
T3 Zhao 2024 Exploring the anti-aging effects of fisetin in telomerase-deficient progeria mouse model doi:10.7717/peerj.16463
T3 Darrah 2026 Fisetin Supplementation Attenuates Premature Vascular Aging Induced by Doxorubicin via Suppression of Cellular Senescence and Mitochondrial Oxidative Stress doi:10.1111/acel.70535
T3 Yousefzadeh 2018 Fisetin is a senotherapeutic that extends health and lifespan doi:10.1016/j.ebiom.2018.09.015
TX Javaid 2024 Neuropharmacology of Fisetin as a Senotherapeutic Agent: Investigating Its Role in Neurodegeneration and Brain Aging doi:10.54393/pjhs.v5i11.2399
TX Rzeski 2026 Natural Bioactive Compounds Targeting Key Hallmarks of Aging: Functional Food Potential of Spermidine, Fisetin, Berberine, and Urolithin A doi:10.3390/nu18152511