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Overview / Research screener / Berberine

OTC Nutraceuticals

Berberine (AMPK activator)

nutrient sensingmetabolic glycemic

Approved medicine for another condition in 1 of 9 markets tracked; sold as a consumer product in 1; in clinical trials in 1.

Evidence so far is from animal studies.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details
main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (6)
  • T3 Jin 2021 Oral administration of berberine represses macrophage activation-associated benign prostatic hyperplasia: a pivotal involvement of the NF-κB doi:10.18632/aging.203434
  • T3 Liu 2023 Berberine mitigates intracerebral hemorrhage-induced neuroinflammation in a gut microbiota-dependent manner in mice doi:10.18632/aging.204642
  • T3 Dang 2020 Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression doi:10.1111/acel.13060
  • TX Guo 2023 The anti-aging mechanism of Berberine associated with metabolic control doi:10.1016/B978-0-12-823679-6.00020-5
  • TX Xu 2017 Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation doi:10.14336/ad.2016.0620
  • TX Rzeski 2026 Natural Bioactive Compounds Targeting Key Hallmarks of Aging: Functional Food Potential of Spermidine, Fisetin, Berberine, and Urolithin A doi:10.3390/nu18152511