Caloric restriction

nutrient sensingautophagy mitophagy

Not a regulated product. No approval pathway exists for this intervention in any market, and none is required to practise it.

1 randomized trial (218 people, 2 years). It improved its main endpoint, a blood or epigenetic marker.

Doses studied: 25% energy restriction.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (11)

T6 Il'yasova 2018 Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial doi:10.1111/acel.12719
T3 Hempenstall 2012 The impact of mid-life dietary switch from ad libitum to dietary restriction and vice versa on metabolic parameters in male C57BL/6 mice doi:10.1186/2046-2395-1-2
TX Speakman 2020 Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis doi:10.1093/nsr/nwaa078
TX Nikhra 2019 Metabolic Disequilibrium and Aging: Modifying Favorably with Calorie Restriction and Calorie Restriction Mimetics doi:10.31031/GGS.2019.04.000596
TX Masoro 2002a Mortality characteristics (Chapter 2, Caloric Restriction: A Key to Understanding and Modulating Aging) doi:10.1016/b978-044451162-1/50002-3
TX Rattan 2010 Hormesis as a Mechanism for the Anti-Aging Effects of Calorie Restriction doi:10.1007/978-90-481-8556-6_13
TX Masoro 2002b Evolution of the anti-aging action of caloric restriction doi:10.1016/b978-044451162-1/50007-2
TX Morris 2010 Calorie Restriction Mimetics and Aging doi:10.1007/978-90-481-8556-6_9
TX Masoro 2002c Mechanisms of the anti-aging action of caloric restriction doi:10.1016/b978-044451162-1/50006-0
TX Masoro 2010 History of Caloric Restriction, Aging and Longevity doi:10.1007/978-90-481-8556-6_1
TX Curtis 2013 Utilizing Calorie Restriction to Evaluate the Role of Sirtuins in Healthspan and Lifespan of Mice doi:10.1007/978-1-62703-637-5_20