Coenzyme Q10 (mitochondrial cofactor)

nad mitochondrialinflammation redox

Sold as a consumer product in 1 of 9 markets tracked; in clinical trials in 4.

1 randomized trial (60 people, 8 weeks). It improved both of its main endpoints, a measure of physical or cognitive function.

Doses studied: 300 mg.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (10)

T7 Fogacci 2024 Effect of Coenzyme Q10 Phytosome Supplementation on Physical Performance in Older Adults with Statin-Associated Asthenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial doi:10.3390/jcm13133741
TX Takahashi 2019 Water-soluble CoQ10 as A Promising Anti-aging Agent for Neurological Dysfunction in Brain Mitochondria doi:10.3390/antiox8030061
TX Cascajo-Almenara 2020 Regulation of Synthesis of Coenzyme Q10 doi:10.1007/978-3-030-45642-9_5
TX Wiciński 2026 Review of Therapeutic Potential of Coenzyme Q10 in Ophthalmology: Focus on Age-Related Macular Degeneration, Glaucoma, and Retinitis Pigmentosa doi:10.3390/antiox15040506
TX López-Lluch 2020 Coenzyme Q10 supplementation in aging doi:10.1016/B978-0-12-818698-5.00018-3
TX Hernández-Camacho 2020 Coenzyme Q10 and metabolic syndrome doi:10.1007/978-3-030-45642-9_11
TX Fladerer 2023 Comparison of Coenzyme Q10 (Ubiquinone) and Reduced Coenzyme Q10 (Ubiquinol) as Supplement to Prevent Cardiovascular Disease and Reduce Cardiovascular Mortality doi:10.1007/s11886-023-01992-6
TX Ashida 2009 Inhibitory Effects of Coenzyme Q10 on Skin Aging doi:10.1016/b978-0-8155-2029-0.50017-x
TX López-Lluch 2019 The Important Role of CoQ10 in Aging doi:10.3390/antiox8120570
TX Barcelos 2019 CoQ10 and Aging doi:10.3390/biology8020028