Dietary protein intake

nutrient sensing

Not a regulated product. No approval pathway exists for this intervention in any market, and none is required to practise it.

3 randomized trials (207 people, 22-26 weeks). 2 improved their main endpoint; 1 found no effect. 1 trial reported no pre-planned main endpoint.

Doses studied: 15 G; 3 g leucine-enriched amino acid protein per sachet.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (12)

T7 Ward 2026 Effect of a PROtein-enriched MEDiterranean diet and EXercise (PROMED-EX) on nutritional status and cognitive performance in older adults at risk of undernutrition and cognitive decline: the PROMED-EX randomized controlled trial doi:10.1016/j.ajcnut.2026.101383
T7 Thavonlun 2026 Combined effect of leucine-enriched amino acid supplementation and resistance training on appendicular skeletal muscle mass index and muscle function in healthy older adults: a randomized controlled trial doi:10.1093/jbmrpl/ziag052
T7 Galyean 2025 The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults: A Randomized Controlled Trial doi:10.21203/rs.3.rs-5868973/v1
T6 Randolph 2019 Effect of essential amino acid supplementation and aerobic exercise on insulin sensitivity in healthy older adults: A randomized clinical trial doi:10.1016/j.clnu.2019.06.017
T5 Tao 2025 Association between dietary protein intake and all-cause mortality among individuals with different estimated glomerular filtration rates: A cohort study from NHANES doi:10.1097/md.0000000000045670
T5 Martínez-Tabar 2026 High plant protein intake decreases all-cause mortality in the “Seguimiento Universidad de Navarra” (SUN) cohort European journal of nutrition doi:10.1007/s00394-026-04037-0
T5 Hessels 2023 Low Sodium Intake, Low Protein Intake, and Excess Mortality in an Older Dutch General Population Cohort: Findings in the Prospective Lifelines-MINUTHE Study doi:10.3390/nu15020428
T5 Daftari 2023 Dietary protein intake and mortality among survivors of liver cirrhosis: a prospective cohort study doi:10.21203/rs.3.rs-2433277/v1
T5 Smeuninx 2020 Amount, Source and Pattern of Dietary Protein Intake Across the Adult Lifespan: A Cross-Sectional Study doi:10.3389/fnut.2020.00025
T3 Rieu 2007 Increased availability of leucine with leucine-rich whey proteins improves postprandial muscle protein synthesis in aging rats doi:10.1016/j.nut.2006.12.013
T3 Yang 2026 Broccoli-Derived Peptides Combined with Leucine Ameliorate D-Galactose-Induced Sarcopenia in Mice doi:10.3390/nu18121997
T3 Huang 2024 Crosstalk between SOD1 and VCP in ALS etiology: Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of SOD1 G93A mice doi:10.1093/hmg/ddae022