High-intensity interval training

nad mitochondrialnutrient sensing

Not a regulated product. No approval pathway exists for this intervention in any market, and none is required to practise it.

2 randomized trials (171 people, 16-26 weeks). Both improved their main endpoint, a measure of physical or cognitive function. 1 trial reported no pre-planned main endpoint.

Doses studied: 3 sessions_per_week intermittent.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (6)

T7 Long-Term Improvement in Hippocampal-Dependent Learning… (2024) Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training doi:10.14336/AD.2024.0642
T7 Duan 2024 Feasibility and Effects of High-Intensity Interval Training in Older Adults with Mild to Moderate Depressive Symptoms: A Pilot Cluster-Randomized Controlled Trial doi:10.21203/rs.3.rs-4160308/v1
T6 Heikkinen 2026 The Divergent Effects of Nicotinamide Riboside and High‐Intensity Exercise Training on Skeletal Muscle Epigenetic Aging doi:10.1111/acel.70638
T3 Tang 2026 High-Intensity Interval Training Modulates Gut Microbial Composition in Aging SAMP6 Mice: A Comparative Study with Moderate-Intensity Continuous Exercise doi:10.21203/rs.3.rs-8745526/v1
TX Zoila 2025 Enhancing active aging through exercise: a comparative study of high-intensity interval training and continuous aerobic training benefits doi:10.3389/fragi.2025.1493827
TX Pidada 2025 High-Intensity Interval Training (HIIT), Anti-Inflammatory Nutritional Intake, and Aging in Obese Patients: Literature Review doi:10.51542/ijscia.v6i3.34