NMN (NAD+ precursor)

nad mitochondrialnutrient sensing

Sold as a consumer product in 1 of 9 markets tracked; in clinical trials in 1.

1 randomized trial (62 people, 9 weeks). It found no effect on any of its 4 main endpoints.

Doses studied: 300 mg.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (6)

T7 Huang 2022 A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults doi:10.3389/fragi.2022.851698
T3 Kane 2026 Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner doi:10.21203/rs.3.rs-10913337/v1
TX Nadeeshani 2022 Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns doi:10.1016/j.jare.2021.08.003
TX Sun 2026 An integrated anti-aging framework targeting NAD+ homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT doi:10.1016/j.redox.2026.104191
TX Imai 2025 NAD World 3.0: the importance of inter-tissue communications between four key tissues through NMN/Slc12a8 and eNAMPT-EVs doi:10.1038/s41514-025-00192-6
TX Soma 2022 The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions doi:10.1007/s11033-022-07459-1