Omega-3 fatty acids (fish oil)

inflammation redoxmetabolic glycemic

Sold as a consumer product in 1 of 9 markets tracked.

1 randomized trial (29 people, 12 weeks). Of its 5 main endpoints, 2 improved, 3 showed no effect.

Doses studied: 14 g/day L-arginine (plus 6 fish oil capsules/day providing 1.92 g EPA and 1.26 g DHA).

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (6)

T7 Yuan 2026 Twelve-week combined arginine and fish oil supplementation is associated with reduced sarcopenia severity: a randomized, double-blind, placebo-controlled study doi:10.3389/fnut.2026.1763219
T5 Zhang 2024 Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank doi:10.7554/elife.90132
T5 Folsom 2004 Fish Intake, Marine Omega-3 Fatty Acids, and Mortality in a Cohort of Postmenopausal Women doi:10.1093/aje/kwh307
T5 Huang 2024 Association between dietary omega-3 fatty acid intake and all-cause mortality in patients with osteoarthritis: a population-based prospective cohort study doi:10.1038/s41598-024-78486-0
T3 Tsuduki 2011 Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice doi:10.1016/j.nut.2010.05.017
TX Harris 2017 The Omega-3 Index and relative risk for coronary heart disease mortality: Estimation from 10 cohort studies doi:10.1016/j.atherosclerosis.2017.05.007