Pterostilbene (sirtuin activator, STAC)

nutrient sensing

Sold as a consumer product in 1 of 9 markets tracked.

2 randomized trials (151 people, 6-8 weeks). 1 improved its main endpoint, a blood or epigenetic marker; 1 found no effect. 1 further trial had no control group; it improved its main endpoint.

Doses studied: 1000 mg/d NR + 200 mg/d PT; 250 mg NR plus 50 mg PT; 250 mg NR plus 50 mg pterostilbene (NRPT 1X); 500 mg NR plus 100 mg pterostilbene (NRPT 2X).

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (7)

T7 Holmes 2026 Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial doi:10.3389/fragi.2026.1773667
T7 Jensen 2022 Nicotinamide riboside and pterostilbene supplementation does not improve muscle stem cell recruitment after injury in elderly humans doi:10.1172/jci.insight.158314
T6 Dellinger 2017 NRPT increases NAD+ levels safely and sustainably in a randomized, double-blind, placebo-controlled trial of 120 healthy adults doi:10.1038/s41514-017-0016-9
T3 Okamoto 2025 Pterostilbene enhances reproductive outcomes and oocyte quality in aged mice without adverse effects doi:10.18632/aging.206287
T3 Liu 2019 PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades doi:10.18632/aging.102418
TX Li 2017 Effect of resveratrol and pterostilbene on aging and longevity doi:10.1002/biof.1400
TX Zeng 2025 Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease doi:10.3389/fnagi.2025.1692777