Time-restricted eating

nutrient sensingautophagy mitophagy

Not a regulated product. No approval pathway exists for this intervention in any market, and none is required to practise it.

2 randomized trials (107 people, 8-26 weeks). 1 improved its main endpoint, a measure of physical or cognitive function; 1 had mixed results. 1 trial reported no pre-planned main endpoint.

Doses studied: 12 hours; 16 hours fasting per day.

Evidence map

each mark is a study; size shows participants; hover, tap or focus for details

main endpoints improvedno effectworsenedmixedobservationalanother intervention, contextsize not reported

Higher rows are closer to a person taking this. A case that rests only on the lower rows rests on animals or cells.

What each study measured

outlined square: the main (primary) endpoint

Harms reported

human studies

Where it is available

by regulator; select a market for its source

If you are tracking this yourself

measures the human studies used, by how repeatable they are

Repeatability is whether the same person measured twice gets the same number. It is not statistical significance. It informs study or protocol design only, never advice for a person.

What would change this picture

each study's own statement

Trials under way

Every study (8)

T7 Tağraf 2026 The effect of simultaneous application of plant-rich ketogenic diet and intermittent fasting on early-to-mid-stage Alzheimer's disease: a randomised controlled trial doi:10.1016/j.jnha.2026.100930
T7 PENG 2026 The Effects of Time-Restricted Feeding and Exercise on Cardiometabolic Health in Sedentary Older Adults: A Randomized Controlled Trial doi:10.1249/mss.0000000000003962
T7 Couto 2025 The impact of intermittent fasting and Mediterranean diet on older adults’ physical health and quality of life: A randomized clinical trial doi:10.1016/j.numecd.2025.104132
T3 Iiams 2026 Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice doi:10.1038/s43587-026-01129-8
T3 Natarajan 2026 Time-restricted feeding improves metabolic flexibility, promotes beiging, and mitigates fibro-inflammation in the adipose tissue of aged mice doi:10.1093/gerona/glag085
T3 Ohno 2026 Middle-aged mice show delayed and destabilized food-anticipatory circadian activity under restricted feeding doi:10.1016/j.jphyss.2026.100071
T3 Zhou 2026 Time‐Restricted Feeding Prevents Cardiac Aging by Entraining Gut Microbiota Clock and Promoting Diurnal Rhythm Autophagy in Prediabetic Mice doi:10.1002/mco2.70910
T3 Briones-Manríquez 2026 Intermittent time-restricted feeding improves physical performance and modulates mitochondrial morphology in a muscle fiber type dependent manner in middle-aged mice doi:10.1038/s41598-026-60902-2